Thyroid hormone receptor expression in the "sick euthyroid" syndrome.

@article{Williams1989ThyroidHR,
  title={Thyroid hormone receptor expression in the "sick euthyroid" syndrome.},
  author={Graham R Williams and Jayne A. Franklyn and James Max Neuberger and Michael C. Sheppard},
  journal={Lancet},
  year={1989},
  volume={2 8678-8679},
  pages={1477-81}
}
To explore the hypothesis that alteration of T3 receptor expression may be an important mechanism controlling the tissue effects of thyroid hormones in the "sick euthyroid" syndrome, specific triiodothyronine (T3) receptor mRNAs were measured in tissues from normal subjects and from patients with liver disease, chronic renal failure, or with multiple organ failure on an intensive care unit (ICU). In all patient groups circulating free thyroxine and free T3 were reduced, while thyroid… CONTINUE READING