Thyroid hormone receptor-beta is associated with coronary angiogenesis during pathological cardiac hypertrophy.

@article{Makino2009ThyroidHR,
  title={Thyroid hormone receptor-beta is associated with coronary angiogenesis during pathological cardiac hypertrophy.},
  author={Ayako Makino and Jorge M Suarez and Hong-gang Wang and Darrell D. Belke and Brian T. Scott and Wolfgang H. Dillmann},
  journal={Endocrinology},
  year={2009},
  volume={150 4},
  pages={2008-15}
}
Insufficient angiogenesis is one of the causes leading to tissue ischemia and dysfunction. In heart failure, there is increasing evidence showing decreased capillary density in the left ventricle (LV) myocardium, although the detailed mechanisms contributing to it are not clear. The goal of this study was to investigate the role of thyroid hormone receptors (TRs) in the coronary microvascular rarefaction under pathological cardiac hypertrophy. The LV from hypertrophied/failing hearts induced by… CONTINUE READING