Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life.

@article{Mai2004ThyroidHR,
  title={Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life.},
  author={Wilfried Mai and Marc Janier and Nathalie Allioli and Laure Quignodon and Thomas A Chuzel and Frederic Flamant and Jacques Samarut},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 28},
  pages={
          10332-7
        }
}
Thyroid hormones are involved in the regulation of many physiological processes and regulate gene transcription by binding to their nuclear receptors TRalpha and TRbeta. In the absence of triiodothyronine (T3), the unliganded receptors (aporeceptors) do bind DNA and repress the transcription of target genes. The role of thyroid hormone aporeceptors as repressors was observed in hypothyroid adult mice, but its physiological relevance in nonpathological hypothyroid conditions remained to be… CONTINUE READING

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