Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon.

@article{Wondisford1989ThyroidHI,
  title={Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon.},
  author={Fredric E. Wondisford and E A Farr and Sally Radovick and H J Steinfelder and J Michael Moates and JOHN H. MCCLASKEY and Bruce D. Weintraub},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 25},
  pages={14601-4}
}
Thyroid hormone regulation of the human thyrotropin beta-subunit gene (TSH beta) was examined in a human embryonal cell line (293). Transient expression studies were performed with chimeric plasmids containing the reporter gene, chloramphenicol acetyltransferase. Sequences in the first exon between +9 and +37 base pairs (bp) enhanced gene expression from the human TSH beta promoter in the absence of thyroid hormone as well as mediated a concentration-dependent triiodothyronine (L-T3) decrease… CONTINUE READING
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