Thyroid hormone-dependent redistribution of the 55-kilodalton monomer of protein disulfide isomerase in cultured glial cells.

@article{Safran1992ThyroidHR,
  title={Thyroid hormone-dependent redistribution of the 55-kilodalton monomer of protein disulfide isomerase in cultured glial cells.},
  author={Michal Safran and Alan P. Farwell and Jack L Leonard},
  journal={Endocrinology},
  year={1992},
  volume={131 5},
  pages={2413-8}
}
In addition to the effects of thyroid hormone that are mediated through interaction with chromatin-associated receptors, T4 modulates the activity of the cellular content of the membrane-associated protein type II iodothyronine 5'-deiodinase (5'D-II) by regulating its degradation through an actin-dependent extranuclear mechanism. Under the influence of thyroid hormone, the substrate-binding subunit of 5'D-II is translocated from the plasma membrane to an intracellular microfilament-associated… CONTINUE READING

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