Thyroid hormone concentrations in epileptic patients

  title={Thyroid hormone concentrations in epileptic patients},
  author={John G Larkin and Graeme J A Macphee and Graham H Beastall and Martin J Brodie},
  journal={European Journal of Clinical Pharmacology},
Anticonvulsants are associated with decreased serum thyroid hormone concentrations. We have studied thyroid function in 54 epileptic patients on a variety of drugs (19 on carbamazepine, 13 on phenytoin, 10 on sodium valproate, 12 on polypharmacy). For comparison, 14 untreated epileptics and 11 healthy unmedicated volunteers were included as controls. Total thyroxine (T4) concentrations were reduced in patients taking enzyme-inducing drugs (carbamazepine and/or phenytoin) compared with both… CONTINUE READING