Thyroid hormone binding by a component of mitochondrial membrane.

  title={Thyroid hormone binding by a component of mitochondrial membrane.},
  author={Kenneth Sterling and P O Milch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={72 8},
The thyroid hormone, triiodothyronine, has been shown to be bound by the intranuclear chromatin protein associated with active DNA, where it is believed to stimulate transcription. Evidence exists that the thyroid hormones have direct action not only on nuclei, but also on mitochondria. Threfore, specific proteins that bind thyroid hormones in the mitochondria should be demonstrable. Mitochondria were isolated from homogenized rat livers by sedimentation through 0.25 M sucrose solution… CONTINUE READING
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