Thyroid hormone attenuates and augments hepatic gene expression at a pretranslational level.

@article{Seelig1981ThyroidHA,
  title={Thyroid hormone attenuates and augments hepatic gene expression at a pretranslational level.},
  author={Steven A. Seelig and Chen Yee Liaw and Howard C. Towle and Jack H. Oppenheimer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1981},
  volume={78 8},
  pages={4733-7}
}
We have attempted to ascertain the proportion of the rat hepatic genome that is under the selective influence of thyroid hormones and to describe the response patterns of individual mRNA sequences in the transition between hypothyroidism and euthyroidism and between euthyroidism and hyperthyroidism. Poly(A)+RNA was extracted from livers of thyroidectomized… CONTINUE READING