Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects.

@article{Morkin2004ThyroidHA,
  title={Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects.},
  author={Eugene Morkin and Paul Ladenson and Steven Goldman and Cynthia Adamson},
  journal={Journal of molecular and cellular cardiology},
  year={2004},
  volume={37 6},
  pages={
          1137-46
        }
}
Thyroid hormone has the unique properties of lowering cholesterol in hypothyroid individuals and improving cardiac performance. Beginning in the 1950s, extensive efforts were made to develop thyroid hormone analogs that could utilize the cholesterol-lowering property in euthyroid individuals without affecting the heart. These efforts culminated in the development of analogs that selectively bind to beta1-type nuclear thyroid hormone receptors (TRs), which are responsible for cholesterol… CONTINUE READING
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