Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease.

@article{Fernndez2004ThyroidHA,
  title={Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease.},
  author={M. Fern{\'a}ndez and A. Giuliani and S. Pirondi and G. D'Intino and L. Giardino and L. Aloe and R. Levi-Montalcini and L. Calz{\`a}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 46},
  pages={
          16363-8
        }
}
Chronic disabilities in multiple sclerosis are believed to be due to neuron damage and degeneration, which follow remyelination failure. Due to the presence of numerous oligodendrocyte precursors inside demyelination plaques, one reason for demyelination failure could be the inability of oligodendrocyte precursor cells to turn into myelinating oligodendrocytes. In this study, we show that thyroid hormone enhances and accelerates remyelination in an experimental model of chronic demyelination, i… Expand
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