Thyroid hormone action on intermediary metabolism

  title={Thyroid hormone action on intermediary metabolism},
  author={M J M{\"u}ller and Hans Joachim Seitz},
  journal={Klinische Wochenschrift},
SummaryIn their physiological concentrations, thyroid hormones stimulate the synthesis as well as the degradation of proteins, whereas in supraphysiological doses protein catabolism predominates. In hyperthyroidism skeletal muscle protein stores suffer depletion which is reflected by an increased urinary N- and methylhistidine -excretion. Due to the enhanced skeletal muscle amino acid release, the plasma concentration of glucoplastic amino acids are often enhanced, contributing by means of an… 

Action of Thyroid Hormones, T3 and T2, on Hepatic Fatty Acids: Differences in Metabolic Effects and Molecular Mechanisms

The inhibitory action on DNL exerted by T2 makes this compound a potential and attractive drug for the treatment of some metabolic diseases and cancer.

Distinct urinary metabolic profiles associated with serum TSH and FT4 concentrations

The findings confirmed metabolic consequences of TH actions, thereby emphasizing the need for distinct interpretation of associations related to serum TSH (hypothalamic-pituitary feedback) or FT4 (tissue specific action) concentrations and offered a new prospect for thyroid function characterization.

The insulin-like growth axis in patients with autoimmune thyrotoxicosis: effect of antithyroid drug treatment.

Comparative study of lipid profile anomalies in thyroid dysfunction

Hypothyroidism demonstrates an atherogenic lipid profile with a positive correlation with serum TSH values and lipid profile since altered lipid profile can predispose to cardiovascular diseases, screening for these in individuals with thyroid dysfunction especially hypothyroidistan needs to made mandatory.

The Impact of Iodine Exposure in Excess on Hormonal Aspects and Hemato-Biochemical Profile in Rats

  • H. Ismail
  • Medicine, Biology
    Biological trace element research
  • 2021
It was concluded that the excess iodine caused hyperthyroidism, which was associated with significant changes in erythrogram and leukogram and alterations in hepatic, renal, and cardiac functions in an iodine dose-dependent damage relationship and the most of negative impacts continued after stopping the administration.

Interaction of levothyroxine with bovine serum albumin: a spectroscopic assay

Both fluorescence quenching and SPR can be used as a stepping stone for the development of a spectroscopic biosensor for LT4 detection, with a limit of detection as low as 0.23 × 10−6 M.



Thyroid hormones and muscle protein turnover. The effect of thyroid-hormone deficiency and replacement in thryoidectomized and hypophysectomized rats.

It would appear that alterations in rates of elongation as well as initiation are involved in the changes in RNA activity, which indicates that tri-iodothyronine can activate athe translational phase of protein synthesis in muscle in the absence of significant quantities of insulin.

Enzyme Response to Thyrotoxicosis and Hypothyroidism in Human Liver and Muscle: Comparative Aspects *

The increase of hexokinase activity (isozyme II) is the most interesting finding in thyrotoxic human muscle because of its possible significance with respect to the elevated metabolic rate.

Effect of experimental hyperthyroidism on skeletal-muscle proteolysis.

The increased amino acid release from isolated muscles and the increased 3-methylhistidine excretion in vivo strongly suggests that hyperthyroidism increases skeletal-muscle proteolysis and the thyroid-hormone concentration may be an important factor in regulating muscle proteolysin.

Thyroid hormone attenuates and augments hepatic gene expression at a pretranslational level.

The proportion of the rat hepatic genome that is under the selective influence of thyroid hormones is ascertained and the response patterns of individual mRNA sequences in the transition between hypothyroidism and euthyroidistan and between euthyoidism and hyperthyroidism are described.

Regulation of hepatic fatty acid-synthesizing enzymes of diabetic animals by thyroid-hormone.

  • D. Das
  • Biology, Chemistry
    Archives of biochemistry and biophysics
  • 1980

Effect of thyroid hormone on the turnover of rat liver pyruvate carboxylase and pyruvate dehydrogenase.

Isotopic studies showed that the changes in the content of pyruvate carboxylase and pyruVate dehydrogenase reflected alterations in the rate of the synthesis of the enzymes with the degradation rates little affected by thyroid status.

Synergism of thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the rat. Mechanisms and implications.

Investigation of the relationship between the administration of triiodothyronine (T3) and a high carbohydrate (CHO) fat-free diet in the induction of lipogenic enzymes in two rat tissues, liver, and fat found a synergistic response between T3 administration and high CHO feeding and the interaction of T3 and the dietary factor occurs at a pretanslational level.

Protein synthesis in perfused rat liver following thyroidectomy and hormone treatment.

Findings indicated an impairment in protein secretion in livers of thyroidectomized rats that persisted after the defect in protein synthesis was corrected by thyroid hormone treatment.