Thyroid hormone action at the cellular level.

  title={Thyroid hormone action at the cellular level.},
  author={Jack H. Oppenheimer},
  volume={203 4384},
A large body of circumstantial evidence suggests that the basic unit of thyroid hormone action is the triiodothyronine nuclear receptor complex. This complex stimulates the formation, directly or indirectly, of a diversity of messenger RNA (mRNA) sequences. A generalized increase in mRNA as well as a disproportionate increase in a limited number of RNA sequences have been demonstrated. Regulation of thyroid hormone effects may be carried out largely at a local cellular level. Highly selective… CONTINUE READING

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