Thyroid growth-blocking antibodies in primary myxoedema

@article{Drexhage1981ThyroidGA,
  title={Thyroid growth-blocking antibodies in primary myxoedema},
  author={Hemmo A. Drexhage and Gian Franco Bottazzo and Lucille Bitensky and J. Chayen and Deborah Doniach},
  journal={Nature},
  year={1981},
  volume={289},
  pages={594-596}
}
Adult primary myxoedema is usually due to an autoimmune thryoiditis characterized by progressive shrinking of the thyroid gland, loss of epithelium, dense infiltration by sensitized lymphocytes and plasma cells with final replacement of the gland by a fibrous scar1. Antibodies directed against thyroglobulin (TgHA) and microsomal antibodies (McHA), detectable years before the onset of hormonal failure, and cell-mediated immune mechanisms contribute to the pathogenesis2. When 90% of the gland is… CONTINUE READING
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