Thyroid endocrine system disruption by pentachlorophenol: an in vitro and in vivo assay.

@article{Guo2013ThyroidES,
  title={Thyroid endocrine system disruption by pentachlorophenol: an in vitro and in vivo assay.},
  author={Yongyong Guo and Bingsheng Zhou},
  journal={Aquatic toxicology},
  year={2013},
  volume={142-143},
  pages={138-45}
}
The present study aimed to evaluate the disruption caused to the thyroid endocrine system by pentachlorophenol (PCP) using in vitro and in vivo assays. In the in vitro assay, rat pituitary GH3 cells were exposed to 0, 0.1, 0.3, and 1.0 μM PCP. PCP exposure significantly downregulated basal and triiodothyronine (T3)-induced Dio 1 transcription, indicating the antagonistic activity of PCP in vitro. In the in vivo assay, zebrafish embryos were exposed to 0, 1, 3, and 10 μg/L of PCP until 14 days… CONTINUE READING

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