Thyroid dysfunction in children with autism spectrum disorder is associated with folate receptor α autoimmune disorder.

@article{Frye2017ThyroidDI,
  title={Thyroid dysfunction in children with autism spectrum disorder is associated with folate receptor α autoimmune disorder.},
  author={Richard Eugene Frye and Rebecca A. Wynne and Shannon Rose and John C Slattery and Leanna Delhey and Marie Tippett and Stephan G Kahler and Sirish C. Bennuri and Stephan Melnyk and Jeffrey M. Sequeira and Edward V Quadros},
  journal={Journal of neuroendocrinology},
  year={2017},
  volume={29 3}
}
Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in autism spectrum disorder (ASD). FRAAs disrupt folate transport across the blood-brain barrier by binding to the FRα. Thyroid dysfunction is frequently found in children with ASD. We measured blocking and binding FRAAs and thyroid-stimulating hormone (TSH), free thyroxine (T4) (FT4), total triiodothyronine (T3) (TT3), reverse T3 (rT3), thyroid-releasing hormone (TRH) and other metabolites in 87 children with ASD, 84 of whom also… CONTINUE READING
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