Thyroid dysfunction and fibrin network structure: a mechanism for increased thrombotic risk in hyperthyroid individuals.

@article{Hooper2012ThyroidDA,
  title={Thyroid dysfunction and fibrin network structure: a mechanism for increased thrombotic risk in hyperthyroid individuals.},
  author={James M. Hooper and Danka J. F. Stuijver and Steve M. Orme and Bregje van Zaane and Katharina Hess and Victor E A Gerdes and Fladia Phoenix and Pat Rice and Kurt A Smith and Saad Alzahrani and Kristina F. Standeven and Ramzi A. Ajjan},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 5},
  pages={1463-73}
}
CONTEXT Hyperthyroidism is associated with increased thrombosis risk, and fibrin clot structure determines susceptibility to vascular thrombotic events. OBJECTIVE Our objective was to investigate clot formation and lysis in hyperthyroidism using observational and interventional studies. DESIGN Ex vivo fibrin clot structure/fibrinolysis and plasma levels of thrombotic/inflammatory markers were investigated in hyperthyroid individuals (n = 24) and matched controls (n = 19), using… CONTINUE READING