Thyroid disruption by low-dose BDE-47 in prenatally exposed lambs.

@article{Abdelouahab2009ThyroidDB,
  title={Thyroid disruption by low-dose BDE-47 in prenatally exposed lambs.},
  author={Nadia Abdelouahab and Alexander Suvorov and J. C. Pasquier and M. F. Langlois and Jean-Paul Praud and Larissa Takser},
  journal={Neonatology},
  year={2009},
  volume={96 2},
  pages={120-4}
}
The purpose of this study was to evaluate whether polybrominated diphenyl ethers (PBDE) at levels reported for human populations affect the thyroid state in pregnant sheep and lambs. Pregnant sheep were exposed to vehicle or BDE-47 (0.2, 2 and 20 microg/kg b.w.) from the 5th to 15th week of gestation by intravenous injections weekly. Thyroid hormone levels and BDE-47 content in the blood of sheep and lambs and adipose tissue were analyzed. We observed a significant decrease in total T(4) and T… CONTINUE READING

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