Thyroid carcinoma: molecular pathways and therapeutic targets

  title={Thyroid carcinoma: molecular pathways and therapeutic targets},
  author={Yuri E Nikiforov},
  journal={Modern Pathology},
Thyroid cancer is the most common malignant tumor of the endocrine system. The most frequent type of thyroid malignancy is papillary carcinoma. These tumors frequently have genetic alterations leading to the activation of the mitogen-activated protein kinase (MAPK) signaling pathway. Most common mutations in papillary carcinomas are point mutations of the BRAF and RAS genes and RET/PTC rearrangement. These genetic alterations are found in >70% of papillary carcinomas and they rarely overlap in… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 143 extracted citations

A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2

Molecular imaging and radionuclide therapy • 2017
View 7 Excerpts
Highly Influenced

Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer • 2018


Publications referenced by this paper.
Showing 1-10 of 84 references

Modern Pathology

S YENikiforov

BRAF is a therapeutic target in aggressive thyroid carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2006

Similar Papers

Loading similar papers…