Thyroid carcinoma: molecular pathways and therapeutic targets

@article{Nikiforov2008ThyroidCM,
  title={Thyroid carcinoma: molecular pathways and therapeutic targets},
  author={Yuri E Nikiforov},
  journal={Modern Pathology},
  year={2008},
  volume={21},
  pages={S37-S43}
}
Thyroid cancer is the most common malignant tumor of the endocrine system. The most frequent type of thyroid malignancy is papillary carcinoma. These tumors frequently have genetic alterations leading to the activation of the mitogen-activated protein kinase (MAPK) signaling pathway. Most common mutations in papillary carcinomas are point mutations of the BRAF and RAS genes and RET/PTC rearrangement. These genetic alterations are found in >70% of papillary carcinomas and they rarely overlap in… CONTINUE READING
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