Thyroid and bone: macrophage-derived TSH-β splice variant increases murine osteoblastogenesis.

@article{Baliram2013ThyroidAB,
  title={Thyroid and bone: macrophage-derived TSH-β splice variant increases murine osteoblastogenesis.},
  author={Ramkumarie Baliram and Andrew Z Chow and Amanda K Huber and Lauren M Collier and M. Rejwan Ali and Syed A Morshed and Rauf Latif and Avelino Teixeira and Meriem Merad and Ling Liu and Liou Y Sun and Harry C. Blair and M Shoaib Zaidi and Terry F Davies},
  journal={Endocrinology},
  year={2013},
  volume={154 12},
  pages={4919-26}
}
It is now firmly established that TSH may influence the physiology and patho-physiology of bone by activating osteoblasts and inhibiting osteoclast activity resulting in relative osteoprotection. Whether this influence is directly exerted by pituitary-derived TSH in vivo is less certain, because we have previously reported that the suppression of pituitary TSH does not remove such protection. Here, we have characterized the functional relevance of a novel form of the TSH-β subunit, designated… CONTINUE READING

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