Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1

@inproceedings{Dame2017ThyroidPA,
  title={Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1},
  author={Keri Dame and Steven Cincotta and Alex H. Lang and Reeti M. Sanghrajka and Liye Zhang and Jinyoung Choi and Letty W Kwok and Talitha Wilson and Maciej M. Kańduła and Stephano Monti and Anthony N. Hollenberg and Pankaj Mehta and Darrell N. Kotton and Laertis Ikonomou},
  booktitle={Stem cell reports},
  year={2017}
}
The clinical importance of anterior foregut endoderm (AFE) derivatives, such as thyrocytes, has led to intense research efforts for their derivation through directed differentiation of pluripotent stem cells (PSCs). Here, we identify transient overexpression of the transcription factor (TF) NKX2-1 as a powerful inductive signal for the robust derivation of… CONTINUE READING
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