Thyroid Hormone Signaling in Oligodendrocytes: from Extracellular Transport to Intracellular Signal

@article{Lee2016ThyroidHS,
  title={Thyroid Hormone Signaling in Oligodendrocytes: from Extracellular Transport to Intracellular Signal},
  author={Jae Young Lee and Steven Petratos},
  journal={Molecular Neurobiology},
  year={2016},
  volume={53},
  pages={6568-6583}
}
Thyroid hormone plays an important role in central nervous system (CNS) development, including the myelination of variable axonal calibers. It is well-established that thyroid hormone is required for the terminal differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes by inducing rapid cell-cycle arrest and constant transcription of pro-differentiation genes. This is well supported by the hypomyelinating phenotypes exhibited by patients with congenital… CONTINUE READING
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