Thyroid Hormone Replacement Therapy

@article{Wiersinga2002ThyroidHR,
  title={Thyroid Hormone Replacement Therapy},
  author={Wilmar M. Wiersinga},
  journal={Hormone Research in Paediatrics},
  year={2002},
  volume={56},
  pages={74 - 81},
  url={https://api.semanticscholar.org/CorpusID:46756918}
}
It is indeed the experience of many physicians that there exists a small subset of hypothyroid patients who, despite biochemical euthyroidism, continue to complain of tiredness, lack of energy, discrete cognitive disorders and mood disturbances.
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Prediction of LT4 Replacement Dose to Achieve Euthyroidism in Subjects Undergoing Total Thyroidectomy for Benign Thyroid Disorders

Patients undergoing total thyroidectomy may require higher doses of thyroxine to achieve euthyroidism when compared to patients with similar anthropometric parameters having primary hypothyroidism, and replacement based on fixed-dose regimens could be a good method if the body weight is taken into consideration.

The different requirement of L-T4 therapy in congenital athyreosis compared with adult-acquired hypothyroidism suggests a persisting thyroid hormone resistance at the hypothalamic-pituitary level.

The different requirement of replacement therapy between adult patients with congenital and those with surgical athyroidism could be explained by a lack of thyroid hormones since fetal life in CH, which could determine a different set point of the hypothalamus-pituitary-thyroid axis.

Liquid liothyronine to obtain target TSH in differentiated thyroid cancer patients.

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Weekly Versus Daily Levothyroxine Tablet Replacement in Adults with Hypothyroidism: A Meta-Analysis

Weekly levothyroxine resulted in less suppression and higher mean serum TSH levels, while still remaining within the normal reference range, suggesting it may be a suitable alternative for non-adherent patients.

Subclinical Hypothyroidism; Natural History, Long-Term Clinical Effects and Treatment

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42 References

Optimal daily levothyroxine dose in primary hypothyroidism. Its relation to pretreatment thyroid hormone indexes.

This study demonstrates that obtaining routine thyroid hormone indexes prior to initiation of replacement levothyroxine therapy may be reliable predictors of the final lev Timothyroxine dose; serum thyroid-stimulating hormone concentration being the best index.

Evaluation of the adequacy of levothyroxine replacement therapy in patients with central hypothyroidism.

The results indicate that the diagnosis of CH is reached at best by measuring TSH and FT4 concentrations, and both FT4 and FT3 serum levels together with some biochemical indexes of thyroid hormone action are all necessary to a more accurate disclosure of over- or undertreated patients.

Aging and the thyroid. Decreased requirement for thyroid hormone in older hypothyroid patients.

Levothyroxine Therapy in Patients with Thyroid Disease

For some patients with nodular thyroid disease, conflicting or insufficient data may not allow an unequivocal consensus recommendation, and in such circumstances, the existing evidence is reviewed and a rational strategy for treatment is provided.

Why does anyone still use desiccated thyroid USP?

The use and misuse of thyroid hormone.

It is important to review the various thyroid hormone preparations, the therapeutic indications, the misuse of thyroid hormone, controversial uses, the thyroid function tests to evaluate the correct treatment dose, and the possible side effects of treatment.

Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.

In conclusion, euthyroidism is not restored in plasma and all tissues of thyroidectomized rats on T4 alone, and these results may well be pertinent to patients on T 4 replacement therapy.

Cardiac effects of long term thyrotropin-suppressive therapy with levothyroxine.

It is indicated that long term levothyroxine therapy at suppressive doses markedly affects cardiac function.

Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Role of triiodothyronine in pituitary feedback in humans.

The findings suggest the possibility that in humans, serum triiodothyronine may play a more important part than serum thyroxine in regulating the serum thyrotropin concentration.

Thyroid hormone levels affected by time of blood sampling in thyroxine-treated patients.

There is a transient increase in thyroid hormone levels for 9 h after an oral levothyroxine dose, which has greatest significance in selecting minimal lev Timothyroxine dosages for suppression of thyrotropin.