Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming

@inproceedings{Chatzitomaris2017ThyroidAR,
  title={Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming},
  author={Apostolos Chatzitomaris and Rudolf Hoermann and John E. M. Midgley and Steffen Hering and Aline Urban and Barbara Dietrich and Assjana Abood and Hermann H. Klein and Johannes Wolfgang Christian Dietrich},
  booktitle={Front. Endocrinol.},
  year={2017}
}
The hypothalamus-pituitary-thyroid feedback control is a dynamic, adaptive system. In situations of illness and deprivation of energy representing type 1 allostasis, the stress response operates to alter both its set point and peripheral transfer parameters. In contrast, type 2 allostatic load, typically effective in psychosocial stress, pregnancy, metabolic syndrome, and adaptation to cold, produces a nearly opposite phenotype of predictive plasticity. The non-thyroidal illness syndrome (NTIS… CONTINUE READING

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