Thyroglobulin suppresses thyroid-specific gene expression in cultures of normal but not neoplastic human thyroid follicular cells.

@article{Ishido2014ThyroglobulinST,
  title={Thyroglobulin suppresses thyroid-specific gene expression in cultures of normal but not neoplastic human thyroid follicular cells.},
  author={Yuko Ishido and Kazuko Yamazaki and Makoto Kammori and Yoshiyuki Sugishita and Yuqian Luo and Emiko Yamada and Tetsu Yamada and Donald F. Sellitti and Koichi Suzuki},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2014},
  volume={99 4},
  pages={E694-702}
}
CONTEXT It was shown in the rat thyroid that thyroglobulin (Tg) stored in the follicular lumen is a potent regulator of thyroid-specific gene expression to maintain the function of individual follicles. However, the actions of Tg as a regulatory molecule in human thyroid have not been studied. OBJECTIVE Our objective was to determine the effect of Tg on gene expression in normal and diseased human thyroid and to examine whether the proposed model of negative-feedback autocrine regulation of… CONTINUE READING

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