Thyroglobulin-pulsed human monocyte-derived dendritic cells induce CD4+ T cell activation.

Abstract

Although thyroglobulin (Tg) would be expected to act as a tumor-associated antigen that might be exploitable by immunotherapy against thyroid cancers, it remains unclear how to effectively enhance the immune response to Tg in human since it is a self-component glycoprotein. We therefore tested whether and how human peripheral blood (PB) monocyte-derived… (More)

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