Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L.

@article{Dunn1991ThyroglobulinPB,
  title={Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L.},
  author={Ann D. Dunn and H E Crutchfield and John T. Dunn},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 30},
  pages={20198-204}
}
The normal provision of thyroid hormones to the body requires their release from the prohormone, thyroglobulin (Tg). Previous work established the importance of cathepsins B, D, and L (formerly designated cysteine proteinase I) to this process but had not defined the points of proteolytic attack for each enzyme. In the present study we labeled rabbit Tg in vivo with sodium 125I and performed limited digestions with cathepsins B, D, and L, purified from human thyroids. The resultant peptide… CONTINUE READING
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