Thyroglobulin molecules internalized by thyrocytes are sorted in early endosomes and partially recycled back to the follicular lumen.

@article{Kostrouch1993ThyroglobulinMI,
  title={Thyroglobulin molecules internalized by thyrocytes are sorted in early endosomes and partially recycled back to the follicular lumen.},
  author={Zdenek Kostrouch and Françoise Bernier-Valentin and Yvonne Munari-Silem and Fabienne Rajas and Rachida Rabilloud and Bernard Rousset},
  journal={Endocrinology},
  year={1993},
  volume={132 6},
  pages={2645-53}
}
Thyroglobulin (Tg) molecules stored in thyroid follicle lumens are heterogeneous in terms of iodine and hormone contents. It has been suggested that thyroid hormone is preferentially produced from the most highly iodinated Tg molecules and that thyrocytes are capable of selecting these molecules. The cellular localization as well as the molecular basis of such a selection process are not known. The present work was undertaken to determine whether there is selectivity at the step of endocytosis… CONTINUE READING
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