Thyroglobulin increases cell proliferation and suppresses Pax-8 in mesangial cells.

@article{Sellitti2001ThyroglobulinIC,
  title={Thyroglobulin increases cell proliferation and suppresses Pax-8 in mesangial cells.},
  author={Donald F. Sellitti and Koichi Suzuki and Sonia Quatelli Doi and Cl{\'a}udia Lagranha and M{\^o}nica Rodrigues Ferreira Machado and Tulio A Matos and Leonard D. Kohn},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={285 3},
  pages={795-9}
}
Thyroglobulin (Tg), has recently been identified as a transcriptional regulator of thyroid-restricted genes. The extrathyroidal expression of several of these genes (including the transcription factor Pax-8) together with the occurrence of specific Tg binding sites suggests a secondary role for Tg as a circulating hormone. In this study, we demonstrate using Northern analysis that Pax-8 is expressed in the mouse mesangial cell, and that its transcript levels are suppressed by Tg. These cells… CONTINUE READING