Thyro-entero-gastric autoimmunity: Pathophysiology and implications for patient management.

  title={Thyro-entero-gastric autoimmunity: Pathophysiology and implications for patient management.},
  author={Edith Lahner and Laura Conti and Francesco Cicone and Silvia Capriello and Maria Teresa Cazzato and Marco Centanni and Bruno Annibale and Camilla Virili},
  journal={Best practice \& research. Clinical endocrinology \& metabolism},
  • E. LahnerL. Conti C. Virili
  • Published 11 December 2019
  • Medicine, Biology
  • Best practice & research. Clinical endocrinology & metabolism

A Graves' Disease Patient Diagnosed as Autoimmune Gastritis with Helicobacter pylori Infection

  • Y. H. AhnK. Hwang
  • Medicine
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research
  • 2022
A case of Graves’ disease (an ATD) is reported in a patient diagnosed with AIG and concomitant H. pylori -induced gastritis based on the rapid urease and serological test results and endoscopic biopsy findings.

Autoimmune Gastritis and Gastric Microbiota

Gastric microbiota composition is challenging to study due to the acidic gastric environment, the difficulty of obtaining representative samples of the entire gastric microbiota, and the possible contamination by oral or throat microorganisms, but innovative molecular approaches based on the analysis of the hyper-variable region of the 16S rRNA gene have been developed, permitting an overall microbial composition view of the RNA gene that is present only in prokaryotic cells.

Type 3 autoimmune polyglandular syndrome (APS-3) or type 3 multiple autoimmune syndrome (MAS-3): an expanding galaxy

This review describes the wide spectrum of the combinations and the intricate relationships between AITD and the other AIDs, excluding Addison’s disease, which are collectively termed type 3 Autoimmune Polyglandular Syndrome (APS-3), and represent the most frequent APS in the world populations.

Autoimmune atrophic gastritis and coeliac disease: A case-control study.

Cobalamin Deficiency in the Elderly

The essential role of cobalamin in humans, the possible causes and impact of deficiency, the diagnostic challenges and the therapeutic options, between old and emerging concepts, are traced, with a particular focus on the elderly.

Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis

This meta-analysis indicates an association between AITD and alteration of microbiota composition at the family, genus, and species levels.

[An adult case of Hashimoto's thyroiditis accompanying pernicious anemia and subacute combined degeneration].

  • K. Shimozono
  • Medicine, Biology
    Rinsho shinkeigaku = Clinical neurology
  • 2021
A 66-year old man presented to the authors' hospital due to gait disturbance and was diagnosed with a combination of Hashimoto's thyroiditis, pernicious anemia and subacute combined degeneration of the spinal cord (SCD), which was autoimmune polyglandular syndrome type3B.

Seeking optimization of LT4 treatment in patients with differentiated thyroid cancer

The aim was to analyze the current knowledge concerning LT4 dose requirements in patients with thyroid cancer according to different therapeutic approaches, taking into account a number of factors causing interference with LT4 efficacy.

Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship

The etiology and risk factors of GC are surveyed, and the mechanisms underlying tumorigenesis induced by H. pylori are analyzed, focusing attention on virulence factor CagA, inflammation, oxidative stress, and ErbB2 receptor tyrosine kinase.

Features of the histostructure of the gastric mucosa in patients with atrophic gastritis combined with thyroid pathology

A connection was found between the pre­sence of nodular changes in the thyroid gland and the degree of atrophy of the mucous membrane of the body of the stomach in patients with chronic atrophic gastritis.



Hashimoto’s Thyroiditis and Autoimmune Gastritis

The term “thyrogastric syndrome” defines the association between autoimmune thyroid disease and chronic autoimmune gastritis, and the most recent achievements on this peculiar association of diseases are summarized.

Autoimmune atrophic gastritis—pathogenesis, pathology and management

The epidemiology, pathogenesis and pathological aspects of autoimmune metaplastic atrophic gastritis are summarized and practical advice for the diagnosis and management of patients with this disease is provided.

Thyro-gastric autoimmunity in patients with differentiated thyroid cancer: a prospective study

Although previous reports found up to one-third of patients with HT to have associated AG, in this cohort AG was extremely rare; however, in most cases, PCA positivity was associated with Hp infection.

The Immunopathogenesis of Chronic Autoimmune Thyroiditis One Century after Hashimoto

  • A. Weetman
  • Medicine, Biology
    European Thyroid Journal
  • 2012
A ‘Swiss cheese’ model for the causation of autoimmune thyroid disease, in which the effects of cumulative weaknesses line up – like the holes in slices of cheese – to allow the catastrophic event of autoimmune destruction to occur.

The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding.

  • R. AjjanA. Weetman
  • Biology, Medicine
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2015
Despite the large number of studies, the mechanistic pathways in HT are still not fully understood and further work is required to enhance knowledge and identify novel preventative and therapeutic clinical targets.

Non-thyroid autoantibodies in autoimmune thyroid disease.

  • A. Weetman
  • Medicine, Biology
    Best practice & research. Clinical endocrinology & metabolism
  • 2005

Common features of patients with autoimmune atrophic gastritis.

  • E. MiceliM. Lenti G. Corazza
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2012

Autoimmune gastritis: Pathologist's viewpoint.

No reliable biomarkers are available for identifying patients at higher risk of developing a gastric neoplasm and standardization of autoimmune gastritis histology reports and classifications in diagnostic practice is a prerequisite for implementing definitive secondary prevention strategies based on multidisciplinary diagnostic approaches.

Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review

This descriptive review updates and summarizes the literature on different nutrient deficiencies in CAAG in order to optimize the treatment and the follow-up of patients affected with CAAGs.