Thymus independent T cell development and selection in the intestinal epithelium.

@article{Poussier1994ThymusIT,
  title={Thymus independent T cell development and selection in the intestinal epithelium.},
  author={Philippe Poussier and Michael Julius},
  journal={Annual review of immunology},
  year={1994},
  volume={12},
  pages={521-53}
}
The presence of intestinal intra-epithelial lymphocytes (IEL) has been appreciated for over 100 years. However, until recently, the IEL were thought to be simply another specialized component of the gut-associated lymphoid tissue (GALT), sharing the same origin as lymphocytes found in other GALT compartments such as the lamina propria, the Peyer's patches, and the mesenteric lymph nodes. While the IEL remain functionally enigmatic, over the last ten years increasing evidence, originally based… CONTINUE READING