Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors.

@article{Wainwright2011ThymusderivedRT,
  title={Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors.},
  author={Derek A. Wainwright and Sadhak Sengupta and Yu Han and Maciej S. Lesniak},
  journal={Neuro-oncology},
  year={2011},
  volume={13 12},
  pages={1308-23}
}
Glioblastoma multiforme (GBM) is a highly malignant brain tumor with an average survival time of 15 months. Previously, we and others demonstrated that CD4(+)FoxP3(+) regulatory T cells (Tregs) infiltrate human GBM as well as mouse models that recapitulate malignant brain tumors. However, whether brain tumor-resident Tregs are thymus-derived natural Tregs (nTregs) or induced Tregs (iTregs), by the conversion of conventional CD4(+) T cells, has not been established. To investigate this question… CONTINUE READING