Thymus-dependent, anti-CD4-induced tolerance to rat cardiac allografts.

  title={Thymus-dependent, anti-CD4-induced tolerance to rat cardiac allografts.},
  author={Bryon C Jaques and H Ahmiedat and J Alastair Gracie and Hilary E Marshall and Stuart Edward Middleton and Eleanor Mary Bolton and J Andrew Bradley},
  volume={66 10},
BACKGROUND Treatment with anti-CD4 monoclonal antibodies (mAbs) leads to induction of transplant tolerance in rodent models, but the cellular mechanisms responsible are poorly defined. In this study, we used a rat model of cardiac transplantation to examine the contribution of the thymus gland to anti-CD4 mAb-induced tolerance. METHODS Pretransplant administration of OX38 mAb partially depletes peripheral CD4 T cells and induces tolerance to fully allogeneic Lewis (RT1l) heterotopic cardiac… CONTINUE READING