Thymus atrophy during Trypanosoma cruzi infection is caused by an immuno-endocrine imbalance.

@article{Prez2007ThymusAD,
  title={Thymus atrophy during Trypanosoma cruzi infection is caused by an immuno-endocrine imbalance.},
  author={Ana R. P{\'e}rez and Eduardo Angel Roggero and Alicia Nicora and Jorge Palazzi and Hugo Oscar Besedovsky and Adriana del Rey and Oscar Adelmo Bottasso},
  journal={Brain, behavior, and immunity},
  year={2007},
  volume={21 7},
  pages={890-900}
}
C57BL/6 mice infected with Trypanosoma cruzi, the causal agent of Chagas' disease, develop severe thymocyte depletion paralleled by an inflammatory syndrome mediated by tumor necrosis factor-alpha (TNF-alpha). The exacerbated inflammatory reaction induces the activation of hypothalamus-pituitary-adrenal (HPA) axis with the consequent release of corticosterone (CT) into the circulation as a protective response. Thymocyte apoptosis has been related to a rise in TNF-alpha and CT levels, and both… CONTINUE READING

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