Thymus and type 1 diabetes: an update.

  title={Thymus and type 1 diabetes: an update.},
  author={Vincent G. Geenen},
  journal={Diabetes research and clinical practice},
  volume={98 1},
Type 1 diabetes (T1D) is a chronic disease resulting from the selective autoimmune destruction of pancreatic islet β cells. The absence and/or breakdown of immune self-tolerance to islet β cells is now recognized as the essential cause for the development of the diabetogenic autoimmune response. For a long time, a failure in peripheral tolerogenic mechanisms was regarded as the main source of an inappropriate immune process directed against insulin-secreting β cells. While defective peripheral… CONTINUE READING
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