Thymus Hormones

@article{Turowski1975ThymusH,
  title={Thymus Hormones},
  author={G. Turowski},
  journal={The Lancet},
  year={1975},
  volume={305},
  pages={314-315}
}
Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathway.
TLDR
The results suggest that Thymax exerts its effects via the mitochondrial pathway of apoptosis and may represent a new class of adjuvants for the treatment of breast cancer.
Thymic reticulo-epithelial cells
  • B. Bodey
  • Biology, Medicine
    Expert opinion on biological therapy
  • 2007
TLDR
The reticulo-epithelial (RE) cellular network of the thymic stromal cellular microenvironment plays a vital role in neuroendocrine regulation and lymphoid cell homing and development and the coexistence of pituitary hormone and neuropeptide secretion is an unique molecular biological phenomenon.
Peripheral Blood Lymphocyte Levels in Normal and Thymectom ~ zed PvG / c Rats
TLDR
Evidence is presented for the proposition that the thymus is able to influence the recirculating lymphocyte population in ways other than through the provision of cells.
Thymic hormones in cancer diagnostics and treatment
  • B. Bodey
  • Biology, Medicine
    Expert opinion on biological therapy
  • 2001
TLDR
It would appear that the control of intrathymic T-lymphocyte maturation and functional maturation involves a complex number of thymic-specific factors and other molecules that rigidly control the intermediary steps in the differentiation process.
CELLULAR AND HUMORAL REQUIREMENTS FOR T‐CELL DEVELOPMENT *
  • O. Stutman
  • Biology
    Annals of the New York Academy of Sciences
  • 1979
TLDR
It is proposed that T-cell differentiation is the consequence of the appropriate or condordant matching of precursor-inducer populations, both at intra- and extrathymic sites and that MHC determinants are critical in permitting the appropriate matching.
Thymic Microenvironment: Selective Activities of Soluble and Insoluble Components
TLDR
In conclusion, STF is believed to trigger a selective migration of lymph‐node‐seeking T cells from the thymus, whereas ITF seems to play a role in the differentiation step preceding that imparted by STT.
Transplacental influence of the thymus
  • P. Mccullagh
  • Biology, Medicine
    The Journal of experimental medicine
  • 1977
TLDR
Pregnancy as a result of mating with syngeneic or allogeneic males produced an ephemeral increase in peripheral blood lymphocyte levels of third and fourth generation thymectomized females, most readily explicable on the basis of a thymus-derived humoral influence acting directly or indirectly to influence the circulating lymphocyte population.
HUMORAL THYMIC FACTORS INFLUENCING POSTTHYMIC CELLS *
  • O. Stutman
  • Biology, Medicine
    Annals of the New York Academy of Sciences
  • 1975
TLDR
It was found that lymphoid and hematopoietic cells from adult or newborn animals acted synergistically with thymus in DC in the restoration of immune functions, and was concluded that adult and newborn tissues contained cells that had already received some thymic influence to become a postthymic population sensitive to the humoral activity of theThymus.