Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells.

  title={Thymosin beta4 targeting impairs tumorigenic activity of colon cancer stem cells.},
  author={Lucia Ricci-Vitiani and Cristiana Mollinari and Simona di Martino and Mauro Biffoni and Emanuela Pilozzi and Alfredo Pagliuca and Maria Chiara de Stefano and Rita Circo and Daniela Merlo and Ruggero de Maria and Enrico Garaci},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={24 11},
Thymosin β4 (Tβ4) is an actin-binding peptide overexpressed in several tumors, including colon carcinomas. The aim of this study was to investigate the role of Tβ4 in promoting the tumorigenic properties of colorectal cancer stem cells (CR-CSCs), which are responsible for tumor initiation and growth. We first found that CR-CSCs from different patients have higher Tβ4 levels than normal epithelial cells. Then, we used a lentiviral strategy to down-regulate Tβ4 expression in CR-CSCs and analyzed… CONTINUE READING


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Thymosin beta-4 directs cell fate determination of human mesenchymal stem cells through biophysical effects.

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