Thymosin beta4 and its posttranslational modifications.

@article{Hannappel2010ThymosinBA,
  title={Thymosin beta4 and its posttranslational modifications.},
  author={Ewald Hannappel},
  journal={Annals of the New York Academy of Sciences},
  year={2010},
  volume={1194},
  pages={27-35}
}
Thymosin beta(4) as well as the other members of the beta-thymosin family are important G-actin sequestering peptides. The chemical properties, the biosynthesis, and posttranslational modifications (PTMs) of these peptides are discussed. During biosynthesis of thymosin beta(4) the initiator methionine is removed and the N-terminus is acetylated. Research on proteomics revealed several acetylated lysine residues and two phosphorylated threonine residues. The enormous number of phosphorylable and… CONTINUE READING