Thymosin beta 4 (T beta 4) in activated platelets.

@article{Nachmias1993ThymosinB4,
  title={Thymosin beta 4 (T beta 4) in activated platelets.},
  author={Vivianne T. Nachmias and Lynne Cassimeris and Rajasree Golla and Daniel Safer},
  journal={European journal of cell biology},
  year={1993},
  volume={61 2},
  pages={
          314-20
        }
}
When resting human blood platelets are stimulated with thrombin, 50 to 60% of the G-actin polymerizes to F-actin within 60 seconds. The increase in F-actin is correlated with a corresponding decrease in the complex of G-actin with T beta 4. Within 5 seconds after stimulation, nucleation sites for pyrene actin polymerization increase 1.5 times in Triton-lysed supernatants. Cytochalasin D, known to inhibit the increase in F-actin after thrombin, also inhibits the fall in T beta 4-actin complex… CONTINUE READING

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