Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells.

@article{Sanders1992ThymosinB4,
  title={Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells.},
  author={Mitchell C. Sanders and Allan L. Goldstein and Yvonne L. Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 10},
  pages={4678-82}
}
Thymosin beta 4 (beta 4) is a 5-kDa polypeptide originally identified in calf thymus. Although numerous activities have been attributed to beta 4, its physiological role remains elusive. Recently, beta 4 was found to bind actin in human platelet extracts and to inhibit actin polymerization in vitro, raising the possibility that it may be a physiological regulator of actin assembly. To examine this potential function, we have increased the cellular beta 4 concentration by microinjecting… CONTINUE READING

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