Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.

@article{Ravindran2010ThymoquinoneP,
  title={Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.},
  author={Jayaraj Ravindran and Hareesh B. Nair and Bokyung Sung and Sahdeo Prasad and Rajeshwar Rao Tekmal and Bharat Bhushan Aggarwal},
  journal={Biochemical pharmacology},
  year={2010},
  volume={79 11},
  pages={1640-7}
}
Thymoquinone (TQ), derived from the medicinal spice Nigella sativa (also called black cumin), has been shown to exhibit anti-inflammatory and anti-cancer activities. In this report we employed polymer-based nanoparticle approach to improve upon its effectiveness and bioavailability. TQ was encapsulated with 97.5% efficiency in biodegradable nanoparticulate formulation based on poly (lactide-co-glycolide) (PLGA) and the stabilizer polyethylene glycol (PEG)-5000. Dynamic laser light scattering… CONTINUE READING