Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer.

@article{Odeh2012ThymoquinoneIL,
  title={Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer.},
  author={Fadwa Odeh and Said Ibrahim Ismail and Rana Abu-Dahab and Ismail S. Mahmoud and Abeer Al Bawab},
  journal={Drug delivery},
  year={2012},
  volume={19 8},
  pages={
          371-7
        }
}
Thymoquinone (2-isopropyl-5-methyl-1,4-benzoquinone) is a herbal-derived drug with potential chemopreventive and chemotherapeutic activity. However, thymoquinone suffers from high hydrophobicity causing poor solubility which limits its bioavailability and high lipophilicity causing poor formulation characteristics. Liposomes are versatile drug carriers that can be used to solve problems of drug solubility, instability, and bio-distribution. In this study, we were able to prepare thymoquinone… CONTINUE READING