Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB.

  title={Thymoquinone chemosensitizes colon cancer cells through inhibition of NF-κB.},
  author={Lida Zhang and Yangqiu Bai and Yuxiu Yang},
  journal={Oncology letters},
  volume={12 4},
In the present study, the effects and molecular mechanisms of thymoquinone (TQ) on colon cancer cells were investigated. Cell viability was determined using a Cell Counting Kit-8 assay, and the results revealed that treatment with TQ significantly decreased cell viability in COLO205 and HCT116 cells in a dose-dependent manner. TQ treatment additionally sensitized COLO205 and HCT116 cells to cisplatin therapy in a concentration-dependent manner. To investigate the molecular mechanisms of TQ… CONTINUE READING


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