Thymoquinone: a small molecule from nature with high therapeutic potential.

@article{Malik2021ThymoquinoneAS,
  title={Thymoquinone: a small molecule from nature with high therapeutic potential.},
  author={Safiya Malik and Amardeep Singh and Poonam Negi and Vijay Kumar Kapoor},
  journal={Drug discovery today},
  year={2021}
}

The Role of Thymoquinone in Inflammatory Response in Chronic Diseases

TLDR
The TQ nanoparticle formulation shows better bioavailability than free TQ, and these formulations are ready for clinical trials to determine their potential as therapeutic agents.

Safety, Stability, and Therapeutic Efficacy of Long-Circulating TQ-Incorporated Liposomes: Implication in the Treatment of Lung Cancer

TLDR
The pharmacological and efficacy profile of PEG-lip-TQ is superior to free TQ, which will pave the way for an exploration of the effect of TQ formulation in the treatment of lung cancer in clinical settings.

Experimental and Theoretical Insights on Chemopreventive Effect of the Liposomal Thymoquinone Against Benzo[a]pyrene-Induced Lung Cancer in Swiss Albino Mice

TLDR
This is the first research to outline the development of TQ formulation against lung cancer considering its low solubility as well as pulmonary delivery challenges and the histopathological analysis of the tissues showed that TQPSL protected the malignancy in the lungs.

Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases

Thymoquinone (TQ) possesses anticonvulsant, antianxiety, antidepressant, and antipsychotic properties. It could be utilized to treat drug misuse or dependence, and those with memory and cognitive

GSH Protects the Escherichia coli Cells from High Concentrations of Thymoquinone

TLDR
It was revealed that TQ concentration has an influence on reactive oxygen species (ROS) production in E. coli strains—at the same thymoquinone concentration, the level of ROS was higher in GSH-deficient E. bacteria strains than in wild type.

Nigella sativa L. and COVID-19: A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature

TLDR
The available facts indicate that NS, NSO, and its various compositions have all the attributes to be used as a promising remedy to prevent, manage, and treat CO VID-19 among high-risk people as well as for the therapy of COVID-19 patients of all age groups as a monotherapy or a combination therapy.

Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

TLDR
The developed nanoemulgel formulation of Nigella sativa oil showed improved antimicrobial activity compared to the plain NSO and was optimized using a Box–Behnken statistical design (quadratic model).

Secondary Metabolites and Their Applications

The identification of secondary metabolites present in both terrestrial and marine species continues to be a fundamental and privileged path for the emergence of new and fundamental natural products

Novel lipid-coated mesoporous silica nanoparticles loaded with thymoquinone formulation to increase its bioavailability in the brain and organs of Wistar rats

Aims The Blood-Brain Barrier (BBB) is a filter for most medications and blocks their passage into the brain. More effective drug delivery strategies are urgently needed to transport medications into

References

SHOWING 1-10 OF 70 REFERENCES

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

TLDR
The potential of thymoquinone as anticancer molecule, its mechanism of action and future usage in clinical applications are discussed, and the optimum time to focus on clinical trials for developing thymosinone as a future drug in cancer therapeutics is now.

Nanocarriers: more than tour de force for thymoquinone

TLDR
This review compiles the different types of polymeric and lipidic nanocarriers (NCs), encapsulating TQ for their improved oral bioavailability, and augmented in vitro and in vivo efficacy, evidenced on various pathologies.

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

TLDR
A brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis is provided.

Thymoquinone is Knocking at the Door of Clinical Trial

TLDR
This review aimed at summarizing the therapeutic potentials in a mechanistic context of a vastly studied quinone, naturally derived product from the seed oil of Nigella sativa called thymoquinone (TQ) with the possibility of redox balancing capacity.

Thymoquinone: a promising anti-cancer drug from natural sources.

The Neuroprotective Effects of Thymoquinone: A Review

TLDR
It is purposed that although experimental studies indicated the beneficial effects of TQ against nervous system problems, better designed clinical trials in humans are needed to confirm these effects.

Therapeutic perspective of thymoquinone: A mechanistic treatise

TLDR
Thymoquinone as phytochemical regulated the pro‐ and antiapoptotic genes and decreased the phosphorylation of NF‐κB and IKKα/β, and further utilization of this compound in diet has been proven effective against different types of cancers.
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