Thymomas express epitopes shared by the ryanodine receptor

  title={Thymomas express epitopes shared by the ryanodine receptor},
  author={{\AA}se Mygland and Goro Kuwajima and Katsuhiko Mikoshiba and Ole-Bj\orn Tysnes and Nils Erik Gilhus},
  journal={Journal of Neuroimmunology},
Myasthenia gravis (MG) patients with thymoma have antibodies against ryanodine receptor (RyR) of skeletal and heart muscle. In this study, thymomas were examined for reactivity with a panel of polyclonal rabbit antibodies against various short peptides of RyR. An antibody against peptide C2 in the transmembrane region of RyR stained thymoma epithelial cells in cryosections of 17/23 thymomas, and detected a 40-kDa peptide in Western blotting of a thymoma membrane fraction. The other RyR… CONTINUE READING


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