Thymoma with immunodeficiency (Good's syndrome): Review of the literature apropos three cases

  title={Thymoma with immunodeficiency (Good's syndrome): Review of the literature apropos three cases},
  author={Spiros Miyakis and Angelos V Pefanis and Freda H. Passam and George R Christodulakis and Paraskevi A Roussou and Theodore D. Mountokalakis},
  journal={Scandinavian Journal of Infectious Diseases},
  pages={314 - 320}
Good's syndrome is the association of thymoma with immunodeficiency, characterized by hypogammaglobulinaemia, depleted B-cells, diminished T-cells and inversion of the CD4/CD8 ratio. The initial clinical presentation is either with a mass lesion-thymoma that is usually benign, or with recurrent infections due to immunodeficiency. Thymectomy usually favourably affects associated conditions, such as pure red cell aplasia, but does not improve hypogammaglobulinaemia, thus the patient remains… 

A case of Good syndrome: Immunodeficiency syndrome associated with a thymoma

A 67-year-old female who had oral thrush for 8 years, recurrent sinopulmonary infections for 2 years, and a history of surgery for an anterior mediastinal mass that proved to be a benign thymoma is presented.

Thymoma with paraneoplastic syndromes, Good's syndrome, and pure red cell aplasia.

A 56-year-old man was examined for a 1.5-year history of recurrent airway infections and sinusitis and diagnosed with pure red cell aplasia (PRCA), which led to less frequent pulmonary infections, but the hypogammaglobulinaemia did not diminish and intravenous gamma globulin therapy was continued every 6 weeks.

Síndrome de Good: Timoma e imunodefi ciência Good's syndrome: Thymoma with immunodefi ciency

A case of a 58 -year -old patient referred to the authors' department for recurrent hypogammaglobulinaemia and esophageal candidiasis is described, where thymectomy does not resolve the immunological abnormalities and IgG replacement treatment to maintain protective level serum IgG is indicated in patients with recurrent infections.

Clinicopathologic features of Good’s syndrome: Two cases and literature review

Good’s syndrome should be considered among the differential diagnoses for patients with unexplained recurrent diarrhea and opportunistic infection, as well as a subset of CVID with thymoma, which had a different clinical-pathological feature from CVID.

Dementia in a patient with Thymoma and hypogammaglobulinaemia (Good's syndrome)

A 75-year-old, caucasian male patient previously subjected to examinations for secondary dementia and recurrent infections revealed paraneoplastic syndrome arose from thymoma, which revealed his immunodeficiency syndrome sustained with frequent opportunistic infections.

Good syndrome, a rare disease that physicians cannot afford to overlook; case report and review of literature.

The infrequency with which the Good syndrome is encountered makes Good syndrome a diagnostic challenge.

Thymoma Associated with Hypergammaglobulinemia: A Case Report

A patient admitted in the authors' hospital with buttock rashes regarded to be zoster of the buttock is presented, and a mass was found in the mediastinum and percutaneous needle biopsy confirmed the diagnosis of thymoma(type B3), the second case reported having thymomas in association with hypergammaglobulinema.

Good's syndrome (immunodeficiency with thymoma): A separate entity with a broad classification: Report of six cases and review of the literature

Good's syndrome is a rare adult‐onset thymoma‐associated immunodeficiency with unknown pathogenesis. Therefore, it should be carefully managed as soon as possible when complications are presented.



What is Good’s syndrome? Immunological abnormalities in patients with thymoma

The cause and pathogenesis of this disorder are unknown, although there is some evidence that the basic defect may be in the bone marrow (pre-B cell arrest, impaired maturation of erythroid and myeloid precursors in some patients).

Sweet's syndrome in a patient with idiopathic myelofibrosis and thymoma-myasthenia gravis-immunodeficiency complex: efficacy of treatment with etretinate.

The patient's general condition unexpectedly improved, with long-lasting suppression of respiratory infections and a slight but consistent improvement of hematological parameters such as Hct, MCV, Hb level, RBC, WBC and lymphocyte absolute counts.

Fatal varicella infection in a child associated with thymoma and immunodeficiency (Good's syndrome).

Evaluation of his immune status during the terminal illness revealed hypogammaglobulinemia and lymphopenia consistent with a diagnosis of Good's syndrome (immunodeficiency with thymoma), the first case of Good’s syndrome reported in a child and the first cases of fatal varicella associated with Good's Syndrome.

Infections in Patients with Immunodeficiency with Thymoma (Good Syndrome): Report of 5 Cases and Review of the Literature

Patients with GS present with a spectrum of sinopulmonary infections and pathogens similar to common variable immunodeficiency (CVID), and compared with patients with CVID, opportunistic infections appear to be more common in patients with GS, and patients withGS may have a worse prognosis.

Thymoma with immunodeficiency (Good's syndrome) associated with selective cobalamin malabsorption and benign IgM‐K gammopathy

Abstract. We have described the first case, to our knowledge, in which recurrent respiratory tract infections were the primary manifestation of thymoma with immunodeficiency (Good's syndrome)

Thymoma, autoimmunity and fatal immunodeficiency.

A 47‐year‐old male presented to us in 1995 with diarrhoea, weight loss, lichen planus, oesophageal candidiasis and streptococcal pneumonia, and Good's syndrome (thymoma and hypogammaglobulinaemia) was suspected and confirmed by CT scans of the mediastinum.

Thymoma with immunodeficiency (Good's syndrome) associated with myasthenia gravis and benign IgG gammopathy.

A case of thymoma with immunodeficiency associated with a rare combination of other parathymic syndromes including myasthenia gravis, benign IgG lambda M component, pernicious anemia, and diabetes is treated.

A patient with pure red cell aplasia and Good's syndrome.

In this case, anemia improved in response to immunosuppressive agents as it did in most of the other cases, but an increased frequency of various infections was seen, since Good’s syndrome is an immunodeficiency condition.

B-cell lymphopenia and hypogammaglobulinemia in thymoma patients

B lymphopenia often occurred in this series of thymoma patients and was related to susceptibility to recurrent infections more than hypogammaglobulinemia, therefore, immunophenotype has to be monitored in follow-up of thye patients because it may reveal significant abnormalities.

Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications.

There is particular concern that infection with mycoplasmas and enteroviruses can be resistant to treatment and the high incidence of lymphoma and gastric carcinoma in patients with common variable immunodeficiency is high-lighted.