Thymocytes and RelB-dependent medullary epithelial cells provide growth-promoting and organization signals, respectively, to thymic medullary stromal cells.

@article{Naspetti1997ThymocytesAR,
  title={Thymocytes and RelB-dependent medullary epithelial cells provide growth-promoting and organization signals, respectively, to thymic medullary stromal cells.},
  author={Marianne Naspetti and Michel Aurrand-Lions and Jenefer Dekoning and Marie Malissen and Franck Galland and David Lo and Philippe Naquet},
  journal={European journal of immunology},
  year={1997},
  volume={27 6},
  pages={1392-7}
}
The thymic medulla is composed of distinct epithelial cell subsets, defined in this report by the reactivity of two novel antibodies, 95 and 29, raised against mouse thymic epithelial cell lines. These antibodies were used to probe the development of medulla in wild-type or mutant thymuses. In CD3 epsilon-deficient mice where thymocyte maturation is arrested at the CD4- CD8- stage, few scattered 95+ and 29+ epithelial cells are found. When few mature thymocytes develop as in CD3- zeta/eta mice… CONTINUE READING
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