Thymineless death in colon carcinoma cells is mediated via fas signaling.

  title={Thymineless death in colon carcinoma cells is mediated via fas signaling.},
  author={Janet A. Houghton and Franklin G Harwood and David M. Tillman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 15},
Fas is expressed constitutively in colonic epithelial cells and is also expressed in colon carcinomas and in cultured colon carcinoma cell lines. However, the potential role of Fas signaling in mediating apoptosis in cells of this type remains unknown. We have developed human colon carcinoma cell models deficient in thymidylate synthase that demonstrate acute (TS- cells) or delayed (Thy4 cells) apoptosis following DNA damage induced by thymineless stress. Complete protection of cells from acute… CONTINUE READING


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Houghton et al

  • C. Barlow, S. Hirotsune, +10 authors 159–171. Medical Sciences
  • Proc. Natl. Acad. Sci. USA 94
  • 1997
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