Thymine metabolism and thymineless death in prokaryotes and eukaryotes.

  title={Thymine metabolism and thymineless death in prokaryotes and eukaryotes.},
  author={S. I. Ahmad and Sandra H Kirk and Abraham Eisenstark},
  journal={Annual review of microbiology},
For many years it has been known that thymine auxotrophic microorganisms undergo cell death in response to thymine starvation [thymineless death (TLD)]. This effect is unusual in that deprivation of many other nutritional requirements has a biostatic, but not lethal, effect. Studies of numerous microbes have indicated that thymine starvation has both direct and indirect effects. The direct effects involve both single- and double-strand DNA breaks. The former may be repaired effectively, but the… CONTINUE READING
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