Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.

Abstract

Thymine DNA glycosylase (TDG) excises T from G·T mispairs and is thought to initiate base excision repair (BER) of deaminated 5-methylcytosine (mC). Recent studies show that TDG, including its glycosylase activity, is essential for active DNA demethylation and embryonic development. These and other findings suggest that active demethylation could involve mC… (More)
DOI: 10.1074/jbc.C111.284620

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@article{Maiti2011ThymineDG, title={Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.}, author={Atanu Maiti and Alexander C. Drohat}, journal={The Journal of biological chemistry}, year={2011}, volume={286 41}, pages={35334-8} }