Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer.

@article{Hu2003ThymidylateSE,
  title={Thymidylate synthase expression predicts the response to 5-fluorouracil-based adjuvant therapy in pancreatic cancer.},
  author={Ying Chuan Hu and Richard A. Komorowski and Shannon J. Graewin and Galen H. Hostetter and O. -P. Kallioniemi and Henry A. Pitt and Steven A. Ahrendt},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 11},
  pages={4165-71}
}
PURPOSE Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU), and TS expression may determine clinical response and survival after therapy with 5-FU in colorectal cancer. 5-FU is also widely used in the adjuvant therapy of pancreatic cancer. Therefore, we explored the hypothesis that TS expression was associated with patient prognosis and the response to adjuvant therapy in pancreatic cancer. EXPERIMENTAL DESIGN Cylindrical tissue cores from a large retrospective… CONTINUE READING
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Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chem4170 Thymidylate Synthase Expression and Pancreatic Cancer

  • M. Etienne, M. Chazal, +13 authors G. Milano
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